Methotrexate is used most commonly to treat cancer because it inhibits rapid cell production.  It was found coincidentally to suppress psoriasis outbreaks, which makes sense since psoriasis causes excessive skin-cell production.  Generally, this drug is not recommended unless absolutely necessary because its side effects can be so severe (even life threatening).

Methotrexate is an extremely harsh drug that is good for fighting cancer when administered in large doses.  In smaller doses it can stop plague psoriasis outbreaks and decrease the effects of psoriatic arthritis.

Many of the detriments of using methotrexate seem to resemble those of accutane (a powerful acne medication) as both adversely affect pregnancies (or even people’s capacity to get pregnant) and have been known to cause lasting liver damage, hair loss and increased skin sensitivity.

The list of potential side effects to using methotrexate goes on and on, affecting what seems like every major bodily function.