Sulfasalazine might be able to treat psoriasis, though not remarkably better than any other anti-inflammatory medicine.  As Sulfasalazine has been known to help people with mild to moderate cases of arthritis, it might also help individuals with psoriatic arthritis.

There are a variety of unpredictable side effects that can occur with this drug, including nausea, inhibition of different blood cell production, temporary infertility in males, depression and liver inflammation.