Keratolytics are topical treatments that soften skin and remove dead skin or scales. The word “keratolytics” is derived from the word “keratin,” which is a major component of the skin as well as durable tissues such as hair or nails. A common keratolytic used for psoriasis is salicylic acid, which is present in Neutrogena’s T/Sal shampoo.
Keratolytics can be used to complement other psoriatic medications. For example, after salicylic acid clears off dead skin from the epidermis, then another treatment such as a coal tar or a topical retinoid will be able to access treatable skin more easily.
Other keratolytics include:
- Urea - The active ingredient for Nair (a common hair removal product). Urea can irritate the skin, cause additional itchiness and can be toxic if applied too liberally.
- Propylene glycol - A moisturizer and solvent, used in everything from anti-freeze to massage oils. There are opposing views as to whether prolonged exposure to propylene glycol causes bodily harm.
- Sulfur - An ingredient found in dandruff, acne and seborrheic dermatitis treatments. Sulfur solutions can be administered in combination with a long list of other chemicals and treatments to treat psoriasis.
- Resorcinol - Used for both psoriasis and acne to soften and/or loosen up hardened skin. Resorcinol can be used as an anti-itching agent as well as an antiseptic.
- Cade oil - Can be mixed with salicylic acid and other antifungal elements to make effective keratolytics / anti-dandruff medications.
