Psoriasis Guru

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Effective Psoriasis Treatments: Keratolytics

Written by Psoriasis Guru on October 19th, 2009

Keratolytics are topical treatments that soften skin and remove dead skin or scales.  The word “keratolytics” is derived from the word “keratin,” which is a major component of the skin as well as durable tissues such as hair or nails.  A common keratolytic used for psoriasis is salicylic acid, which is present in Neutrogena’s T/Sal shampoo.

Keratolytics can be used to complement other psoriatic medications.  For example, after salicylic acid clears off dead skin from the epidermis, then another treatment such as a coal tar or a topical retinoid will be able to access treatable skin more easily.

Other keratolytics include:

  • Urea - The active ingredient for Nair (a common hair removal product).  Urea can irritate the skin, cause additional itchiness and can be toxic if applied too liberally.
  • Propylene glycol - A moisturizer and solvent, used in everything from anti-freeze to massage oils.  There are opposing views as to whether prolonged exposure to propylene glycol causes bodily harm.
  • Sulfur - An ingredient found in dandruff, acne and seborrheic dermatitis treatments.  Sulfur solutions can be administered in combination with a long list of other chemicals and treatments to treat psoriasis.
  • Resorcinol - Used for both psoriasis and acne to soften and/or loosen up hardened skin.  Resorcinol can be used as an anti-itching agent as well as an antiseptic.
  • Cade oil - Can be mixed with salicylic acid and other antifungal elements to make effective keratolytics / anti-dandruff medications.

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