Hydroxyurea is considered a good alternative for those who are physically unable to take methotrexate.  Like methotrexate, hydroxyurea inhibits DNA synthesis (cell reproduction) thus limiting the effects of psoriasis and other hyperprolific cells such as cancer.

Hydroxyurea is considered “second” to methotrexate for the purposes of treating psoriasis because it’s generally not as effective while it still poses many severe health risks.

It should be noted at the same time that Hydroxyurea occasionally suppresses psoriasis outbreaks where methotrexate fails.  Thus, it is the case for all psoriasis cases that different treatments will work for different people depending on their genetic make-up and daily habits (including diet and overall health).

Hydroxyurea is marketed under the brand names “Hydrea” and “Droxia.”