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Psoriasis News: Stelara Is Now FDA Approved

Thursday, October 1st, 2009

A few days ago I wrote an article anticipating the eventually approved of Stelara by the FDA and now… it is done.  As of right now, you can obtain this groundbreaking new psoriasis treatment in the UK, the general European Union, Canada and the United States for the treatment of moderate to sever plaque psoriasis (the most common type of psoriasis) by prescription only.

Stelara (a product of Johnson and Johnson) is groundbreaking for the dramatic improvements it produces in people suffering from plaque psoriasis (70% improvement according to FDA sanctioned tests), convenient dosing (5 shots per year) and it seems to pose very mild, if any, side effects.  It is a selective immunosuppressant… which is to say that it is designed to target and suppress only certain proteins (interleukin-12 and interleukin-23), which are key players in creating the symptoms of plaque psoriasis.  The active ingredient is called ustekinumab.

As you might be able to guess by the word “immunosuppressant,” however, Stelara is the kind of drug that can open you up to infections that otherwise would have been held off by your body”s natural defenses.

Most researchers have believed for a while now that psoriasis throws off the immune system, causing an excess of skin cell production, which results in the itchy, red, scaly, irritated skin symptoms that have made this disease notorious.  This is why drug companies have been focusing on drugs that either alter or suppress the body’s immune system.  Altering the immune system is one of the most direct ways medical professionals know of to attack psoriasis.

Also of note: Stelara is supposed to be very expensive, upwards of $16,000 per year (if you had to pay for the whole thing out of pocket).  My optimistic guess for why it would cost this much (for 5 doses) is that a lot of money was poured into research and development, thus a high cost is needed to recoup.  Of course, drug companies are businesses first and foremost, so this is probably also a factor.  But if Stelara works and people are willing to pay, then I guess it is worth it.

My psoriasis is not nearly severe enough to justify using this drug (right now anyway).  My game plan as of now is to seek out natural, less expensive, lifestyle oriented solutions to root out the disease and keep it rooted out.

New Psoriasis Drug from Johnson and Johnson: Stelara (Ustekinumab)

Monday, September 28th, 2009

The National Institute for Health and Clinical Excellence (NICE) has approved Johnson and Johnson’s new psoriasis drug, Stelara, for use in the U.K.  The drug has also been approved for use in Canada but is still under review by the FDA.

It’s also expensive:  10,000 pounds, or about $16,000 USD per year.

Stelara works by targeting two specific proteins that play a major role in the body’s immune system: Interleukin 12 and Interleukin 23.  Regulating these proteins should reduce swelling and bring excessive skin cell production under control.

Administering this new drug should prove to be much more convenient than most other psoriasis treatments — it only needs to be taken 5 times a year via injection.  Thus far it has also proven to be safe.

In light of the unpredictable nature of psoriasis it is good to have as many treatment options, or as many avenues of attack, as possible.  In addition to developing resistance to certain treatments over time, psoriasis can also behave differently depending on the individual in question.  A treatment that works well for one individual might not work for another person and visa versa.

At this stage in the game Stelara is meant to treat moderate to severe plaque psoriasis (this is the most common type of psoriasis).  It is viewed as an option that should be tried only after other alternatives have proved to be ineffective.  This will most likely include a large percentage of the masses who currently suffer from psoriasis since so many are at their wits’ end trying to find an effective treatment for it.

Can Vitamin D Treat Psoriasis?

Monday, September 28th, 2009

Vitamin D is used around the world as one (of many) supplements that can treat psoriasis.  As an initial observation, this makes sense since Vitamin D is the nutrient that the body absorbs as a result of being out in the sun.

However, it should be noted that taking too much vitamin D (or derivatives thereof) can cause a variety of hazardous side effects, including hypercalcemia (too much calcium in the blood),  which causes nausea, disorientation, kidney failure, high blood pressure and coma.  Also, if you already have too much calcium coursing through your veins then vitamin D can increase your risk of developing kidney stones.  How much of a Vitamin D supplement is “enough’ (not too much) varies case by case, but the general consensus in the medical community is “less is more.”

Definitely consult your doctor before loading yourself up with vitamin D.

Calcipotriol (aka calcipotriene in the U.S.) is a derivative of vitamin D, which is administered as a topical treatment (cream) to treat psoriasis.  This drug has been proven to suppress excessive skin cell production and thus dramatically improve plaque psoriasis in particular.  It has also proven to be much safer than many other Vitamin D psoriasis treatments.  In the U.S. it is called “Dovonex” and is available by prescription only.

What Is Methotrexate?

Friday, September 25th, 2009

Methotrexate is used most commonly to treat cancer because it inhibits rapid cell production.  It was found coincidentally to suppress psoriasis outbreaks, which makes sense since psoriasis causes excessive skin-cell production.  Generally, this drug is not recommended unless absolutely necessary because its side effects can be so severe (even life threatening).

Methotrexate is an extremely harsh drug that is good for fighting cancer when administered in large doses.  In smaller doses it can stop plague psoriasis outbreaks and decrease the effects of psoriatic arthritis.

Many of the detriments of using methotrexate seem to resemble those of accutane (a powerful acne medication) as both adversely affect pregnancies (or even people’s capacity to get pregnant) and have been known to cause lasting liver damage, hair loss and increased skin sensitivity.

The list of potential side effects to using methotrexate goes on and on, affecting what seems like every major bodily function.