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Psoriatic Arthritis – Dealing With Joint Pain

Wednesday, November 25th, 2009

For most people, when you think of the word “arthritis” and the typical arthritis sufferer, you think of someone’s grandmother, with gnarled and knobby fingers, struggling to open a jar or hold a pen. The truth is that there are a number of different types of arthritis and they can hit people in the 20’s, 30’s, 40’s or even in childhood! One such type of arthritis is known as psoriatic arthritis. This particular form of inflammatory arthritis afflicts somewhere between 10 – 30% of those who suffer from the skin condition psoriasis. Typically appearing about 10 years after the first signs of psoriasis, psoriatic arthritis tends to afflict its sufferers much earlier in life than other forms of arthritis.

Arthritis is any one of a group of conditions that cause damage to the joints of the body. There are more than 100 different types of arthritis, with psoriatic arthritis being one of the more common forms. As with other types of arthritis, psoriatic arthritis is characterized by an inflammation of the joints. It can also be accompanied by tendinitis and severe swelling of the fingers and toes. For people that are suffering from this ailment, the swelling and tendinitis can cause just as much, if not more discomfort than the actual joint inflammation itself.

Treatment of psoriatic arthritis is similar to the treatment of basic osteoarthritis, and can include taking anti-inflammatory medications, such as naproxen. Other treatment options include the injection of specific corticosteroids into the affected joints or the prescription of certain immunosuppressants that can help reduce the body’s inflammatory response and therefore reduce the discomfort. The most severe cases are also being treated with special forms of DNA therapy, where different series of DNA that are not normally found together are combined, creating new, artificial DNA which can help prevent irreversible joint damage.

Psoriasis is estimated to affect somewhere between 2 and 3% of the western population of the world. It is a largely hereditary condition, and while treatable is not curable. Those that have psoriasis and then are later afflicted by psoriatic arthritis fall into one of five different categories of arthritis. Nearly half will have symmetrical arthritis and have joints on both sides impacted. The second most common form is asymmetrical, where only joints on one side of the body are affected. Regardless of what form you are struggling with, it is essential that you consult a physician at the first sign of arthritis, so that you will have the best array of treatment options available to you.

Hydrocortisone (Cortisol) as a Psoriasis Treatment

Sunday, October 18th, 2009

Hydrocortisone cream

The active ingredient present in hydrocortisone is cortisol.  Cortisol is a mild steroid / hormone (a corticosteroid) that the human body creates naturally but can also be produced synthetically for medicinal uses.  Hydrocortisone, a topical cream, is the most common form of cortisol.

When applied 2-3 times a day Hydrocortisone has been proven to alleviate swelling, itching and general skin irritations (some of the most common psoriasis symptoms). It is available by prescription only.

Cortisol seems to be useful for treating psoriasis because of it’s suppressive effect on the immune system.  It signals to the immune system to stop producing T-Cells (which are designed to fight off hostile cells), which in turn brings down swelling.  Excessive T-cell production has also been linked to the scaling that characterizes plaque psoriasis.  Bringing skin cell production under control in this manner most likely helps to eliminate itchiness (pruritus).  Cortisol also regulates some aspects of metabolism, which also may help to suppress skin cell proliferation.

A friend of mine was prescribed hydrocortisone for the some psoriasis breakouts that occur on his forehead and chin. The effect of this topical cream have been a complete clearing of all scales and itching. He also says that he has experienced no adverse side-effects.

Hydrocortisone ingredients

What is Taclonex?

Saturday, October 10th, 2009

Taclonex is a vitamin D / topical steroid hybrid that was created with the intention of improving the efficacy and response time of to Dovonex.  It was approved by the FDA in 2008 for use with psoriasis and is available by prescription only.

Patients using Taclonex typically see an improvement in their plaque psoriasis within one week.  It is not recommended that this drug be used for more than 4 consecutive weeks.

Taclonex relieves the two main issues that characterize plaque psoriasis — inflammation and scaly skin.  Separately, these are the two effects that topical steroids and synthetic vitamin D solutions have on psoriasis.

Taclonex has many of the same side-effects as topical steroids (skin irritation and thinning) and vitamin D (too much calcium in the body sensitivity to sunlight).  There are a variety of other less common, more severe side effects that can occur with people who have allergic reactions or who are have pre-existing conditions.  Be sure to tell your doctor about any supplements or other drugs you may be taking if the possibility of taking Taclonex arises.

What is Dovonex (Calcipotriene)?

Saturday, October 10th, 2009

Dovonex (a.k.a. calcipotriene or calcipotriol) is a topical psoriasis treatment used to control the excessive skin cell production (plaque psoriasis).  It a vitamin D derivative that is available by prescription only.   It is also known as calcipotriol, or calcipotriene.

The exact mechanism by which Dovonex controls skin cell production is not known, though it is thought to have a regulatory effect on T-cell activity.  T-cells are a part of the immune system that bring about excessive skin cell growth in response to psoriasis.

Typical dosage for Dovonex is twice daily to affected areas of the skin.

It was discovered that the corticosteroids helped to speed up the effects of Dovonex, so these two are sometimes prescribed simultaneously.  Mixing steroids with synthetic vitamin D brought about a new drug that was approved by the FDA in 2008 called “Taclonex.”

Dovonex has also been mixed with other topical treatments such as anthralin, Tazorac and coal tar to make it more effective.

Anyone on Dovonex should be careful about staying in the sun since it has been shown to increase the skin’s sensitivity to UV rays, in particular by speeding up the rate at which skin cancer develops.  Other side effects include excessive calcium absorption, irritation and a worsening of psoriasis symptoms.  Pregnant women are strongly advised against using this drug.  On rare occasions Dovonex has also been known to cause mood swings, a stretching / thinning of the skin, pair follicle pustules, dizziness and abdominal pain.