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Hydrocortisone (Cortisol) as a Psoriasis Treatment

Sunday, October 18th, 2009

Hydrocortisone cream

The active ingredient present in hydrocortisone is cortisol.  Cortisol is a mild steroid / hormone (a corticosteroid) that the human body creates naturally but can also be produced synthetically for medicinal uses.  Hydrocortisone, a topical cream, is the most common form of cortisol.

When applied 2-3 times a day Hydrocortisone has been proven to alleviate swelling, itching and general skin irritations (some of the most common psoriasis symptoms). It is available by prescription only.

Cortisol seems to be useful for treating psoriasis because of it’s suppressive effect on the immune system.  It signals to the immune system to stop producing T-Cells (which are designed to fight off hostile cells), which in turn brings down swelling.  Excessive T-cell production has also been linked to the scaling that characterizes plaque psoriasis.  Bringing skin cell production under control in this manner most likely helps to eliminate itchiness (pruritus).  Cortisol also regulates some aspects of metabolism, which also may help to suppress skin cell proliferation.

A friend of mine was prescribed hydrocortisone for the some psoriasis breakouts that occur on his forehead and chin. The effect of this topical cream have been a complete clearing of all scales and itching. He also says that he has experienced no adverse side-effects.

Hydrocortisone ingredients

Tazorac (Tazarotene) – A Unique Topical Psoriasis Medication

Wednesday, October 7th, 2009

Tazorac is a topical retinoid, which means it is a vitamin A derivative.  Retinoids are what I would classify as one of the “harsher” types of drugs, since they affect immune system functionality and can thus result in some severe side effects.  Besides psoriasis, Tazorac is also commonly used to treat acne.  By my understanding, it is the topical equivalent of Accutane.

Chemists / pharmaceutical firms have developed a variety of different retinoids that have varying effects depending on the patient and their particular condition.  Tazorac’s active ingredient, tazarotene, is considered a “third generation” retinoid.

Administering retinoids via a topical solution may pose less health risks than taking them orally.  On the downside, people using Tazorac to treat psoriasis will inevitably see their symptoms return (sometimes months) after usage of this medication is stopped.  Several months of remission after stopping treatment is a long time compared to other topical psoriasis medications, but this still falls short of the goal, which is to be psoriasis free for life.

Tazorac comes in the form of a non-staining gel or a cream solution.  It was approved by the FDA in 1997 at which time it was hailed as a major breakthrough in topical skin treatment.

Tazorac has proven to be an effective psoriasis treatment as it regulates skin cell growth and keeps swelling down.  Some doctors even prescribe it alongside topical steroid treatments and have seen ever greater remissions.  It can be applied to any surface of the body including the scalp, though contact with more sensitive areas such as the eyelids is not recommended.

Tazorac is available only through a doctor’s prescription.  Tazarotene is also marketed under the brand names Avage and Zorac (also available by prescription only).

Side effects of using Tazorac include in dry and sometimes irritated skin.  Pregnant women should definitely not use Tazorac as this similar medications have been proven to cause birth defects.

Bleach Baths Found to Help with Eczema and Psoriasis Outbreaks

Monday, October 5th, 2009

Eczema is term that can be applied broadly to any kind of skin condition that results in flaky, irritated, itchy skin. Psoriasis has many of the same characteristics of this general condition, including cause (hereditary), symptoms (described above) and effective treatments (light therapy, for example).

The similarities between psoriasis and eczema inspired me to mention this new treatement that has been found to help people recover from severe eczema and/or psoriasis: Bleach baths.  You might ask your doctor if he/she thinks this would be worth a try.

Promising results for this treatment have been reported through a variety of news outlets and online forums (including here and here for example).

The prescribed concentration for these bleach baths is between a 1/4 and 1/8 cup bleach for a full bath.  This seems to kill any infection on the surface of the skin, thus allowing the body heal from the damaging effect of these skin conditions. Everyone I read about did not reporting smelling like bleach (or a swimming pool) and, in any case, it is recommended that the person soaking in the bath rinse off with regular water afterward.  Also, the consensus amongst people trying out this treatment is that soaking once or twice a day in bleach is needed to decrease outbreaks.

Incyte Announces Promising Results from New Topical Psoriasis Treatment Tests

Thursday, October 1st, 2009

Incyte has released some promising results regarding their new topical psoriasis treatment, INCB18424.  Patients with mild to moderate plaque psoriasis have reported up to 54% improvement after using this treatment.

INCB18424 is a cellular inhibitor, blocking some of the immune system’s functionality in particular.  Specifically it blocks JAK (Janus Kinase 1&2), which affect cytokine activity within the immune system.

Why is this a good thing?  The general consensus amongst the medical community is that psoriasis makes the immune system going haywire, which produces those notoriously psoriatic symptoms (scaly, itchy, irritated skin).  Thus, blocking some aspects of the body’s immune system will most likely block psoriasis flare ups.

INCB18424 is expected to have longer lasting effects and it should be more easily tolerated by a larger number of patients then the corticosteroids (a kind of steroid) and other topical treatments that are in everyday use right now for treating psoriasis.

INCB18424 has not yet been released for use by the general public.