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Tazorac (Tazarotene) – A Unique Topical Psoriasis Medication

Wednesday, October 7th, 2009

Tazorac is a topical retinoid, which means it is a vitamin A derivative.  Retinoids are what I would classify as one of the “harsher” types of drugs, since they affect immune system functionality and can thus result in some severe side effects.  Besides psoriasis, Tazorac is also commonly used to treat acne.  By my understanding, it is the topical equivalent of Accutane.

Chemists / pharmaceutical firms have developed a variety of different retinoids that have varying effects depending on the patient and their particular condition.  Tazorac’s active ingredient, tazarotene, is considered a “third generation” retinoid.

Administering retinoids via a topical solution may pose less health risks than taking them orally.  On the downside, people using Tazorac to treat psoriasis will inevitably see their symptoms return (sometimes months) after usage of this medication is stopped.  Several months of remission after stopping treatment is a long time compared to other topical psoriasis medications, but this still falls short of the goal, which is to be psoriasis free for life.

Tazorac comes in the form of a non-staining gel or a cream solution.  It was approved by the FDA in 1997 at which time it was hailed as a major breakthrough in topical skin treatment.

Tazorac has proven to be an effective psoriasis treatment as it regulates skin cell growth and keeps swelling down.  Some doctors even prescribe it alongside topical steroid treatments and have seen ever greater remissions.  It can be applied to any surface of the body including the scalp, though contact with more sensitive areas such as the eyelids is not recommended.

Tazorac is available only through a doctor’s prescription.  Tazarotene is also marketed under the brand names Avage and Zorac (also available by prescription only).

Side effects of using Tazorac include in dry and sometimes irritated skin.  Pregnant women should definitely not use Tazorac as this similar medications have been proven to cause birth defects.

What do Antioxidants Have to Do With Psoriasis?

Wednesday, October 7th, 2009

An antioxidant helps to prevent the oxidation of other molecules.  Oxidation is reaction by which one molecule takes electrons from another molecule.  This process is facilitated by the presence of oxygen.  Oxidation leaves the latter molecule unstable, as a free radical.  These free radicals spin off, wreaking havoc on other cells in chain reactions that can cause widespread cellular damage.

Antioxidants step in to cut off this process before it begins by allowing themselves to become oxidized instead of any other surrounding cells.   Antioxidants are more prone to loose their electrons than the other cells around them, which they do without causing additional, collateral damage.

Common antioxidants include: Vitamins A, E and C as well as Selenium and other herbal supplements.  The body also creates its own antioxidant enzymes.

Connection to psoriasis: Free-radicals, mentioned above, have been attributed to the development of the scaly skin that is a common side effect of psoriasis.

The relationship between oxidants / antioxidants and psoriasis is still being explored.  A connection has been drawn mainly from an imbalance of these molecules in skin affected by psoriasis, including an abundance of oxidants and a dearth of antioxidants.

The goal with antioxidants, as with most aspects of health, is balance.  If you’re healthy all around then your body will have a healthy level of antioxidants.  Taking too many antioxidant supplements with the intention of super-charging your system will most likely cause more damage than good.

Is Vitamin A an Effective Psoriasis Treatment?

Monday, September 28th, 2009

Vitamin A is believed by many to promote healthy skin in general.  As far as skin conditions go, it seems to be taken more commonly to treat acne.  Accutane is based on a derivative of Vitamin A.

Vitamin A helps your body resist psoriasis the same way that being healthy in general helps your body resist this condition.

Researchers tend to agree that psoriasis is related to misbehaving T-cells, thus, since vitamin A promotes healthy T-Cell activity, it may help to suppress psoriasis.  Vitamin A promotes effective body regeneration and discourages abnormal cell development.

It is possible to take too much vitamin A, so consult your doctor if you have any questions about what is right amount.  Consuming excessive amounts of vitamin A will cause it to store up in the body, eventually becoming toxic.

Vitamin A should be taken with other supplements since it needs the presence of other vitamins and minerals to work effectively.  In particular, be sure you are also taking it vitamin E, zinc and eating protein.

Side effects of taking too much vitamin A include hair loss, jaundice, nausea, blurred vision and decreased mental capacities.